Beyoncé's 2019 GLAAD Media Awards speech was irreplaceable.

It wasn't long before the global superstar had guests cheering after taking the stage alongside her famous husband, Jay-Z, to accept the prestigious Vanguard Award on Thursday night in Los Angeles.

During the star-studded ceremony, the 23-time Grammy-winning songstress told the crowd she was "overwhelmed" as she delivered an impassioned speech following a medley performance by Shangela as well as an introduction from Morris Singletary, Janet Mock, Ty Hunter and Lena Waithe.

"We were not expecting any of those incredible presenters and just super honored and overwhelmed. I have already cried. I put a run in my stocking," the mother of three told the crowd as she began. "I would say that one of the most beautiful memories from our tour was looking out every night and seeing the hardest gangster trapping out right next to the most fabulous queen, full out, respecting and celebrating each other. That was dope! That's the beauty of great partnership, connecting people who at first glance seem worlds apart," she continued at the event, sponsored by Ketel One Family-Made Vodka. Read more via E News